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Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as highly effective anti-obesity therapies, producing weight loss of approximately 520% across clinical trials
The strongest human evidence is topical, including the Leyden 2002 photoaging trial and a 2023 IRB-approved 21-woman topical NEEL gel study reporting an average 28% increase in skin collagen density at 3 months
Sermorelin compared to lifestyle interventions Growth hormone optimization through sermorelin should complement rather than replace foundational health practices
b trials enrolled people with established cardiovascular disease and/or elevated cardiovascular risk factors (see original publications)
Loose skin is also more prone to infections, sores and rashes, which can be painful and uncomfortable
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