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A second direction of the interrelationship between psoriasis and obesity indicates that patients with psoriasis have elevated levels of inflammatory cytokines, particularly TNF-, which can lead to metabolic abnormalities, including insulin resistance, and may consequently lead to the development of obesity (211)

For instance, certain herbal compounds alleviate depression by activating the Creb1/Six3os1 axis or modulating the GhrlEdn1/Mecp2/P-mTOR/VEGFA pathway [536, 537]

Fang X, Ardehali H, Min J, Wang F

4.4.1.5) and glyoxalase II (Gly II