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Endogenous FA has been suggested as a causative agent for the DNA repair-deficient condition Fanconi Anaemia 8,9,10

The main cellular sources of ROS are (1) mitochondria, where electron-transport-chain (ETC) leads ROS production through leakage of electrons during oxidative phosphorylation, (2) NADPH oxidases (NOXes), which generate superoxide and hydrogen peroxide (H 2 O 2 ) through transferring electrons from NADPH donors to oxygen, regulating both immune response and homeostatic ROS signalling (3) peroxisomes, which produce H 2 O 2 as a byproduct during breakdown of metabolic reactions such as breakdown of fatty acids and (4) xanthine oxidase, which generates superoxide and H 2 O 2 as a byproduct of oxidative hydroxylation of hypoxanthine in purine metabolism

Ensure you are also getting enough co-factors like Vitamin C and Selenium, and consider if lifestyle factors like high stress or lack of sleep are hindering your progress.

M., Jones, D

High dosages of selenium were discovered in a clinical experiment to lower septic shock mortality [101]