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According to FDA prescribing information for semaglutide and liraglutide, hypersensitivity reactions are rare but possible

Nearly half of all heart attack patients experience persistent narrowing of tiny blood vessels in the heart muscle even after the main blocked artery has been reopened during emergency treatment

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In 2024, there were 8.4 million prescriptions and $8.6 billion in spending on GLP-1s in Medicaid, and 21.8 million claims and $27.5 billion in gross spending (not excluding rebates) on GLP-1s in Medicare (Figure 1)