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Biochem Soc Trans 1998
"Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects." The Journal of Clinical Endocrinology & Metabolism 81.12 (1996): 4249-4257
For hyperpigmentation disorders, tretinoin may prevent the transcription of the enzyme tyrosinase which minimizes melanogenesis
My view is that the pronounced effect of GLP-1 analogues on gastric emptying is not only an important mediator of satiety and reduced food intake but also a likely mechanism responsible for its effect on type 2 diabetes and cardiovascular disease
This process can decrease inflammatory signals that stimulate melanocytes
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