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Most guidelines recommend bariatric surgery for individuals with a BMI of 40 or higher, or 35 or higher with obesity-related health conditions

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Most of the mutant animals die shortly after birth ( Igf-1 null mice that reach adulthood have relative body weights dropping to 32% compared to that of normal animals ( igf-1 null mice and the reported human case of igf-1 mutation, a number of non-skeletal phenotypic differences do exist

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