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Discussion Our studies demonstrate that intra-colonic administration of propionate stimulates the concurrent release of both GLP-1 and PYY in rodents, and demonstrate in vitro , and for the first time in vivo , that FFA2 deficiency impairs SCFA-induced gut hormone secretion

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They might play an integral role in obesity-related disease management in conjunction with long-standing options such as diet, lifestyle modification and bariatric surgery

Therefore, further research is needed to clarify whether this effect translates into meaningful rhythm disturbances