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No Phase 3 MASH trial has been registered in the TRIUMPH programme as of 2026

and 2) evaluate the strength and quality of evidence for the reliability and validity of the PROMs identified

Here are the average weight loss results based on the dose and timeline: 1 mg: 7.2% in 24 weeks and 8.7% in 48 weeks 4 mg: 12.9% in 24 weeks and 16.3% in 48 weeks 8 mg: 17.3% in 24 weeks and 23.9% in 48 weeks 12 mg: 17.5% in 24 weeks and 24.2% in 48 weeks Placebo: 1.6% in 24 weeks and 2.1% in 48 weeks The retatrutide clinical trials are still ongoing, with a phase IV planned after the current phase III

The synergistic effects of combining both phases is what gives such great long-lasting results

Rev Endocr Metab Disord 15(3):233242