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The medication is also titrated, or started at a lower dose and increased over time, to minimize side effects
Benefits such as lower blood sugar or weight reduction take time to build
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In a study on HCC cell lines and mouse models with in situ tumors, it was shown that MET activation can phosphorylate the 56th tyrosine residue and trigger glycogen synthase kinase 3 (GSK3), resulting in decreased PD-L1 expression [137]
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