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Stop taking Metformin tablets and call your healthcare provider right away if you get any of the following symptoms of lactic acidosis: Feel very weak and tired Have unusual (not normal) muscle pain Have trouble breathing Have unusual sleepiness or sleep longer than usual Have unexplained stomach or intestinal problems with nausea and vomiting, or diarrhea Feel cold, especially in your arms and legs Feel dizzy or lightheaded Have a slow or irregular heartbeat You have a higher chance of getting lactic acidosis if you: Have kidney problems

Adherence Two participants (both in the placebo arm) were lost to follow-up

Treatment options for gastrointestinal cancers depend on the stage and location of the cancer but may include surgery, radiation therapy, chemotherapy, targeted therapy, or a combination of these approaches

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GIP primarily stimulates insulin secretion, affects glucagon in glucose-dependent ways, and influences fat metabolism