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These discoveries have given rise to the idea that bipolar disorder is a bioenergetic and metabolic disease with psychiatric manifestations, and that disruptions in the molecular and cellular signalling networks that regulate brain energy metabolism in a biphasic manner are a primary, sufficient cause of bipolar disorder-related phenomena [189]

The strongest research base is still preclinical rather than large-scale human randomized trials, but the consistency of the findings is one reason BPC-157 has gained so much attention