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10 Data on the impact of ivermectin on multidrug resistance is mainly in animal studies, but benefit has been demonstrated with agents such as vincristine

This is the basis for oral and capsule research formats, especially in gut-focused models

Linked to this, antimicrobial resistance is a worldwide problem derived from the acquired or innate bacterial resistance to common antimicrobials, including antibiotics [10], and mainly caused by their misuse [11]