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These uncertainties do not make the CNS findings irrelevant, but they do mean the area should be described as exploratory and preclinical rather than established

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Modulates cortisol and stress hormone rhythms that interfere with sleep quality, promoting balanced neuroendocrine function that supports natural sleep onset and maintenance throughout the night

In addition, altered thyroid hormones levels may cause changes in the number and activity of mitochondrial respiratory chain components which represent the principal cellular site of ROS production, ultimately leading to changes in the cellular redox environment and increased ROS generation (57, 58)