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The ghrelin receptors on the pituitary gland (the gland naturally involved with growth hormone, or hGH synthesis) are also known as Growth Hormone Secretagogue receptors (GHS-R)
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Animal studies have reported various effects, including potential lifespan extension in rodent models and improvements in certain biomarkers associated with aging
In animal and tissue-model studies, IGF-1 LR3 has been examined for its role in myoblast and satellite-cell proliferation, myotube differentiation, and tissue-repair pathways
Its distinguishing trait is a narrow, clean action on the GH-secretagogue receptor with little activity elsewhere which in the founding pharmacology meant GH went up while cortisol and prolactin stayed near baseline
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