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The general tolerability profile observed across the phase 2 program is that of the incretin class: predominantly gastrointestinal adverse effects nausea, vomiting, diarrhea, constipation that are usually dose-related and most prominent during dose escalation
Known brands include Wegovy, celebrated for weight management, and Ozempic, famous for managing type 2 diabetes
Found prioritizes multidisciplinary support
The MHRA issued a Drug Safety Update in January 2025 about monitoring and managing gastrointestinal side effects with tirzepatide
Licensed oral weight management options in the UK include orlistat
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