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IGF-2 is composed of 67 amino acids and has growth-promoting activity similar to that of IGF-1, but its expression pattern is not controlled by growth hormone (10)
doi:10.1056/NEJMoa2032183 4
The American Academy of Ophthalmology Preferred Practice Pattern regarding patients with diabetic retinopathy and no DME recommends considering anti-VEGF only in patients with severe NPDR
A color change within the same vial over time is different and concerning
These medications work by mimicking the action of naturally occurring incretin hormones, which enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety through central nervous system pathways
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