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Ratios of log 2 -normalized transcript count data were generated for SLD Dpp4 / mice versus baseline SLD WT mice, HFHC-fed Dpp4 / mice versus baseline HFHC-fed WT mice, and HFHC-fed Dpp4 hep/ mice versus baseline HFHC-fed Dpp4 GFP mice

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Electrostatic similarity analysis Electrostatic similarity calculations were performed using OpenEye toolkit by combining ROCS for shape-based alignment and EON for electrostatic similarity calculations

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