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Elevated urinary tiglyglycine is associated with deficiency in the isoleucine catabolic enzyme, 2-methylacetoacetyl-CoA thiolase, and is also associated with propionic acidemia
2017 study reported improvements in aged mice that were sustained through the observation period, suggesting that senescent cell clearance produces durable benefits once senescent cells are eliminated, their pro-inflammatory SASP burden is removed, allowing tissue recovery that persists beyond the treatment window
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Research on their absorption and long-term clinical benefit is still evolving, and results may vary depending on the product and the condition being studied
Reactive stress is what this is
