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The observed risk for metformin-induced vitamin B 12 deficiency demonstrated an additive effect for rs1801222 genotype, with both AG (OR 1.37 [95% CI 1.21, 1.54], I 2 =18.6%) and AA (OR 2.30 [95% CI 1.99, 2.65], I 2 =0%) genotype groups being at increased risk vs the GG group
Additionally, craving scores increased after alcohol consumption across both groups, as shown by a significant main effect of time ( 2 (1) = 6.15, p = 0.013, f = 0.57, Fig
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