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The authors conclude that the renal benefits cannot solely be explained by weight reduction or risk factor reduction, although these may contribute, and the mechanisms of kidney protection are likely to be multifactorial and may include decreased oxidative stress, inflammation and fibrosis in the kidney

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FDA labeling does include a warning about acute kidney injury in the postmarketing setting, often associated with severe gastrointestinal adverse reactions leading to volume depletion

When discussing severity, it is helpful to include a sentence that describes what was happening at that moment