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TNF induces both pro- and anti-apoptotic signaling pathways
In ob/ob mice and Zucker rat models, it has consistently reduced fat mass, decreased epididymal and brown adipose tissue weight, and improved lipid profiles without affecting lean tissue or glucose homeostasis
By promoting the clearance of these dysfunctional cells, FOXO4-DRI holds promise as a therapeutic agent in rejuvenating tissues and improving healthspan
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10.1074/jbc.M309832200 J
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