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Klotho deficiency and aging caused cardiac metabolic disorders and myocardial injury as evidenced by decreased cardiac ATP generation and increased serum levels of CK-MB (creatinine kinase-MB) and troponin 1 in KL (/) and aging mice (Online Figures III and XII)

Chiu WY, Shih SR, Tseng CH

Con: Since most of what you take is digested instead of absorbed, it can feel like a waste

A 52-week phase 2 trial on AMG133 in people with overweight and obesity is ongoing (NCT05669599)

Retatrutide is a novel triple receptor agonist targeting GLP-1, GIP, and glucagon receptors, placing it in a distinct class from existing weight-management treatments such as semaglutide and tirzepatide