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Toxicology, 77 (12), 8190
The symptoms are based on a complex pathology that includes degeneration of dopaminergic neurons in the substantia nigra [156] and a striatal loss of dopamine [157], as well as accumulation and aggregation of alpha-synuclein [158], the main component of Lewy bodies [159], in various regions of the brain [160]
A small pilot study designed to evaluate the safety of lipoic acid in 30 people with relapsing or progressive multiple sclerosis found that treatment with 1,200 to 2,400 mg/day of oral lipoic acid for two weeks was generally well tolerated (see Safety) (95)
Some compounded tirzepatide formulations include B12 (methylcobalamin), and researchers report improved energy levels with this addition
