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Semaglutide, as a GLP-1R agonist, works very similarly to GLP-1 by potentiating glucose-stimulated insulin secretion from the pancreatic -cells while suppressing glucagon secretion by pancreatic -cells [103]
Apr 2018;14(1):24-29
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Since they only slightly increased endogenous GLP-1 concentrations, evidence from clinical trials confirmed that DPP-4i sitagliptin, vildagliptin, and anagliptin did not influence gastric emptying ( Limitation This study evaluated the potential effects of GLP-1 RAs liraglutide and DPP-4i sitagliptin on bowel cleaning quality, tolerability, and safety
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