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Still, there are cases where B12 injections are the better bet
The compound may work synergistically with NAD+ precursors like NMN or NR, potentially enhancing metabolic benefits
B12 injections are indicated for patients with documented deficiency, including those with pernicious anaemia, malabsorption disorders, following gastric surgery, or with neurological symptoms suggesting B12 deficiency
Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs
Risks of taking vitamin B12 injections include taking unnecessarily high amounts (which arent always absorbed properly anyway) and experiencing interactions with other medications.
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