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Their seemingly miraculous properties have been praised by tech CEOs, podcaster Joe Rogan, and celebrities such as Gwyneth Paltrow, Jennifer Aniston, and Kim Kardashian, who says her daily regimen changed my life. But many doctors are alarmed by a craze that has thousands of people injecting themselves with substances of dubious origin and whose long-term effects are unknown

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Those individuals must take dietary supplements to compensate for the failure of the body to get sufficient vitamin b12 levels from normal whole foods

This genetic anomaly in MeCbl synthesis leads to the accumulation of homocysteine, a condition termed hyperhomocysteinemia or homocystinuria [94, 100], (Fig