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Populations to avoid: Pregnant and breastfeeding individuals, individuals with active neuroendocrine conditions, and those on ACTH-axis medications should not use DSIP without specialist guidance

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The same quality considerations apply to compounded semaglutide and research versus pharmaceutical grade peptides generally

Because topical research uses concentration-based dosing rather than absolute-mass dosing, the researcher must formulate the peptide into a carrier base at a target concentration, then apply a consistent volume to the research area