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[13] One Dutch study found that after adjustment for gender and age, there was a statistically significant negative association between the use of metformin and vitamin D status, with those who did not use a vitamin D supplement having levels of vitamin D 14.4 percent lower than controls

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10.1002/gepi.21965 7 BunielloA.MacArthurJ

They subsequently developed another analog, Ac-Nle- cyclo [Asp-His-D-Phe-Arg-Trp-Lys]-NH 2 ), which they called "Melanotan II"