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Clinical challenges and mitigation strategies Core clinical and research challenges With the widespread clinical use of platinum-based chemotherapeutics, long-term in vivo platinum accumulation has emerged as a critical yet underrecognized clinical challenge, serving as the core toxicological driver of impaired long-term quality of life and adverse health outcomes in cancer survivors
In 1920, the doctors may have been surprised to see that their patients skin was getting lighter by the day
One critical factor in timeline is the management of die-off reactions, known clinically as the Herxheimer reaction: as Candida organisms are killed, they release toxins that can temporarily worsen symptoms including headaches, fatigue, and joint pain
In the second case, even though the rats are fasted, the rapid reuptake of cysteine, glycine, and glutamate by the liver cells insures that the synthesis of GSH declines relatively slowly and therefore the observed half-life is long
