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Rapidly increasing energy metabolism in vulnerable individuals can lead to adverse effects, such as mania or psychosis
doi: 10.1007/BF00429088 30 SeinoSWelshMBellGIChanSJSteinerDF
It was first reported by Sawyer, Hruby, Hadley and colleagues in the Proceedings of the National Academy of Sciences in 1980, and it departs from native human alpha-MSH at only two of thirteen positions: norleucine replaces the oxidation-prone methionine at position 4, and the phenylalanine at position 7 is inverted to its D-enantiomer
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Kamen DL, Cooper GS, et al
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