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The time to steady state for LCPT based on t 1/2eff is shown in Figure 2
Compound Receptors Peak trial weight loss Lean mass as share of loss Semaglutide (Ozempic/Wegovy) GLP-1 ~14.9% (STEP-1, 68 wk) ~39% Tirzepatide (Mounjaro/Zepbound) GLP-1 + GIP ~20.9% (SURMOUNT-1, 72 wk) ~25-40% Retatrutide GLP-1 + GIP + GCGR ~24.2% (Phase 2, 48 wk) Comparable class range Best for understanding the takeaway: the percentage of loss that is lean mass is roughly constant across the class
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Regulatory guidance still recommends stopping the drug if pancreatitis is suspected, but theres no strong evidence of a direct link
Accumulated platinum ions can induce oxidative stress damage and activate the neuroinflammatory cascade, leading to DRG neuron damage, axonal degeneration, and nerve conduction disorders, and ultimately trigger chronic sensory neuropathy (Lin et al
