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Safety, adverse events, and how they factor into which medication may be right for you Common side effects of semaglutide and tirzepatide include: Nausea Vomiting Diarrhea Stomach pain Decreased appetite Indigestion Belching Constipation Headache Risk of low blood sugar Semaglutide and tirzepatide can cause serious side effects such as pancreatitis (inflammation of the pancreas), gallbladder problems, changes in vision, serious allergic reactions, and kidney issues