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[2] [3] There is limited research on berberine's effects during pregnancy or lactation, and women who are pregnant, planning pregnancy, or breastfeeding should consult their GP, midwife or pharmacist before using any berberine products

In contrast, the observed response to adjuvant weight loss medication with phentermine, phentermine-topiramate extended release, lorcaserin, or naltrexone/bupropion was significantly better in gastric bypass and gastric banding patients compared with SG according to an observational study in 209 patients 1 year following BS

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Should be used with caution in patients with a history of gastrointestinal disorders, as it may exacerbate symptoms