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OxLDL loading significantly depleted cytosolic and mitochondrial anisotropy in a time-dependent manner (Fig 4D), suggesting that oxLDL loading increased GSR-mediated NADPH consumption in both compartments

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The substantial weight reduction observed with tirzepatide monotherapy (15-21% body weight in clinical trials) suggests that any perceived benefits likely reflect tirzepatide's pharmacological effects rather than synergistic action

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