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Oxygen flux rates were normalized to mg of protein added determined with a BCA protein analysis test (Pierce)

Interestingly, these seemingly dichotomous effects of E2 on intracellular bioenergetics could be a result of differential receptor activation, as E2 was found to inhibit F0F1-ATP synthase activity via non-genomic mechanisms in a human osteoclastic cell line (FLG 29.1 cells) (200)

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These monocytes further get differentiated into TAMs, which in turn secrete factors such as EGF, VEGF, and TGF-, driving tumor invasion, spread, and new blood formation (109)