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It is contraindicated in people with a personal or family history of medullary thyroid carcinoma (MTC) or those with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), a rare genetic condition

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This creates blood levels 25% or more above intended trough and significantly increases side effect risk

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Efficacy and safety of short- and long-acting glucagon-like peptide 1 receptor agonists on a background of basal insulin in type 2 diabetes: A meta-analysis