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NICE recommends disease-modifying antirheumatic drugs (DMARDs) such as methotrexate as first-line treatment, with biologic therapies (TNF inhibitors, IL-6 inhibitors) or JAK inhibitors for patients with inadequate response

2022 R&D Spend: In 2022, Boehringer Ingelheim spent 5.05 billion ($5.32 billion USD) on R&D, a 22.29 percent increase from the 4.13 billion ($4.88 billion USD) the company spent on R&D in 2021

It is less expensive than GLP-1 options and may be covered by some plans, but has more contraindications (not suitable for patients with cardiovascular disease or history of certain conditions)

12, fluorescence image analysis demonstrated that D-CuP achieved enhanced cellular internalization

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