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A U-shaped dose-response and time-of-infusion curve has been documented an important design consideration for DSIP research, as both sub-threshold and supra-threshold doses may produce attenuated effects relative to the optimal dose range

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A higher level of oxidative stress was detected in patients with NASH compared to NAFLD and a reduction in the levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and GGT, as markers of oxidative stress, was highlighted in NASH patients treated with GSH, with a consequent reduction of alanine transaminase (ALT)

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The primers used for amplification were as follows: GPX4-Forward 5-ATGAGCCTCGGCCGCCTTTG-3