It is an intracellular metabolic-enzyme modulator, which is why its research read-outs are things like NAD+ levels and adipocyte gene expression, not how full you feel. That mechanistic distinction is the single most important thing to understand before looking at any dose number
However, B12 shots may support weight loss efforts in ways that matter during a structured program
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In animal studies, it has been linked to blood vessel growth at injury sites and tissue protection
(For general B12 background, see the Mayo Clinic explainer.) How much weight can someone lose with lipotropic injections