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Face changes become visible earlier than body changes for most people, with jawline definition and reduced facial puffiness appearing by month 2-3
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Many people begin to notice subtle changes within 12 weeks, especially improvements in energy, mood, and motivation
Confirmatory secondary endpoints are change from baseline in AD Cooperative Study Activities of Daily Living MCI (ADCS-ADL-MCI) score and time to progression to a CDR global score of 1.0 among participants with a CDR global score of 0.5 at baseline, both assessed at week 104 (see discussion and Table 2)