Multiple cellular processes are considered to contribute to this functional decline and these are collectively referred to as the hallmarks of aging and these include processes like genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis 1
Two things happening at once, by design rather than accident
This review highlights NAD+ as a central regulator of cellular metabolism and stress responses, demonstrating that disruptions in NAD+ balance contribute to aging, metabolic disease, cancer, and neurodegeneration
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