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Lower levels of glutathione are associated with high blood sugar and result in oxidative stress and tissue damage

The mean HbA1c was reduced by 1.5% (16.4 mmol/mol) with 0.5 mg semaglutide compared with 1.1% (12.1mmol/mol) with 0.75mg dulaglutide and this difference was statistically significant, in favour of semaglutide

The balance between efficacy and tolerability is therefore critical

Before administration, patients should remove the pen from refrigeration and allow it to reach room temperature for approximately 30 minutes, as injecting cold medication may increase discomfort

REDEFINE 1 and REDEFINE 2 ran 68 weeks, with the first ~16 weeks dedicated to dose titration