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5.2 Acute Pancreatitis Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including RYBELSUS [see Adverse Reactions (6)]

Published preclinical research uses it to investigate the FOXO4-p53 protein interaction and p53-dependent responses in cellular-senescence models