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Abstract Purpose of Review This review will summarize the most contemporary trials for glucagon-like peptide 1 receptor agonists (GLP1-RA) and sodium-glucose cotransporter 2 inhibitors (SGLT2-i) and present guidance on management and recommendations on adjunctive tapering of insulin in patients with insulin-dependent diabetes mellitus, which we term de-insulinization. Recent Findings GLP1-RA and SGLT2-i are the principal classes of diabetes medications evidencing cardiovascular benefit
Tracking kidney function and checking hydration is crucial throughout treatment
Food and Drug Administration approved a 7.2-milligram dose of Danish drugmaker Novo Nordisk's semaglutide
Consistent $199 pricing regardless of dose level (brand-name is $499 for 2mg)
Avoid overcharging and deep discharging to prevent irreversible damage
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