CD4 + T lymphocytes can secrete cytokines such as interferon, IL-6, IL-17 and TNF-, which further induce the production and release of MMP and the activation and aggregation of neutrophils in the body, thereby destroying lung tissue and activating elastase, ultimately leading to elastin hydrolysis and emphysema formation
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Moreover, it demonstrates the regulatory role of microbial metabolites produced by the gut microbiota, such as short-chain fatty acids, amino acids, lipids, etc., in the tumour progression
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