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J Funct Foods 5(1):4452
doi: 10.5306/wjco.v7.i1.122 9 AllesMCGardiner-GardenMNottDJWangYFoekensJASutherlandRLet al
GLP-1 and NMDA receptors are expressed throughout the mammalian brain and, although reports indicate that GLP-1 analogues engage central appetite circuits through distinct subpopulations of neurons (most notably in the brainstem and the hypothalamus) 36 , feedforward neural pathways modulated by inhibition of NMDA receptors specifically in GLP-1-receptor-positive neurons may differ from those engaged by exclusive activation of GLP-1 receptors
Despite its initial success, Byetta, derived from Gila monster venom, was less convenient and offered more modest weight loss compared to todays GLP-1 drugs
M., Hopkins, C
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