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Common causes of injection discomfort: Needle penetration through pain-sensitive dermis Rapid injection speed causing tissue distension Cold medication temperature Medication pH and formulation characteristics Injection into areas with less subcutaneous fat Reusing injection sites without adequate rotation Muscle tension at the injection site can also amplify pain perception

Support by NIH NINDS 1K08NS057824 and Johns Hopkins BSI and NARSAD Young Investigator Award to TWS., National Institute of Mental Health (MH-092443 Silvio O

Huang CS, Luo GA, Huang MJ, Chen ES, Young TH, Chao YC

Though GLP-1s can be really good at improving blood sugar control, people with diabetes are less likely to see significant weight loss

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