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For individuals experiencing mild gastrointestinal upset from B12 supplements (uncommon but possible with high doses), taking the supplement with breakfast may improve tolerance

Your risk of osteoporosis is increased when you have a decreased bone mineral density

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Gastrectomy for any reason (eg, gastric cancer, bariatric surgery) increases the risk of deficiency because parietal cells, the source of intrinsic factor, are removed (17

The peptide dissolves readily in bacteriostatic water without needing the osmolality adjustment that saline provides