retatrutide triple agonist gip glp-1 glucagon phase 3 2025 Retatrutide, a agonist, delivered 30.3% weight loss at two years in 3. The headlines state: → 70 lbs average loss on 12mg at 80 weeks (28.3% of body weight) → The most intensive medical obesity

We dont have large-scale trials

You want it to be a bit more gradual

The timing and duration of receptor activation also influences outcomes

Data availability Details of the search strategy and list of identified articles can be found at Abbreviations BGM: Blood glucose monitoring CGM: Continuous glucose monitoring CSII: Continuous subcutaneous insulin infusion CVOT: Cardiovascular outcomes trial DKA: Diabetic ketoacidosis DPP-4i: Dipeptidyl peptidase-4 inhibitors DSMES: Diabetes self-management education and support ETD: Estimated treatment difference GIP: Glucose-dependent insulinotropic polypeptide GLP-1 RA: Glucagon-like peptide-1 receptor agonist(s) HF: Heart failure HHF: Hospitalisation for heart failure MACE: Major adverse cardiovascular events MNT: Medical nutrition therapy NAFLD: Non-alcoholic fatty liver disease NASH: Non-alcoholic steatohepatitis SGLT1i: Sodiumglucose cotransporter-1 inhibitor SGLT2i: Sodiumglucose cotransporter-2 inhibitor(s) TZD: Thiazolidinedione UACR: Urinary albumin/creatinine ratio References Rodriguez-Gutierrez R, Gionfriddo MR, Ospina NS et al (2016) Shared decision making in endocrinology: present and future directions

La premire est celle que l'on pourrait qualifier de " naturelle " et que la plupart des gens essaient depuis toujours