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10 In large adult randomized controlled trials, tirzepatide demonstrated substantial weight-loss efficacy, with mean body weight reductions of up to 20.9% over 72 weeks, surpassing outcomes observed with semaglutide monotherapy
For a Wednesday injection schedule, a surgery planned the following Monday is within the seven-day window and calls for omission of that weeks dose
Sleep disturbances were not reported at notably higher rates in the semaglutide groups compared to placebo groups, and insomnia is not listed as a common adverse reaction in the UK SmPC
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